Search results for "Hardy-Weinberg Equilibrium"
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TP53 codon 72 polymorphism and cervical cancer
2009
Background Cervical cancer is caused primarily by human papillomaviruses (HPV). The polymorphism rs1042522 at codon 72 of the TP53 tumour-suppressor gene has been investigated as a genetic cofactor. More than 80 studies were done between 1998 and 2006, after it was initially reported that women who are homozygous for the arginine allele had a risk for cervical cancer seven times higher than women who were heterozygous for the allele. However, results have been inconsistent. Here we analyse pooled data from 49 studies to determine whether there is an association between TP53 codon 72 polymorphism and cervical cancer.Methods Individual data on 7946 cases and 7888 controls from 49 different st…
Modeling of Hardy-Weinberg Equilibrium Using Dynamic Random Networks in an ABM Framework
2023
Hardy-Weinberg equilibrium is the fundamental principle of population genetics. In this article, we present a new NetLogo model called “Hardy-Weinberg Basic model v 2.0”, characterized by a strict adherence to the original assumptions made by Hardy and Weinberg in 1908. A particularly significant feature of this model is that the algorithm does not make use of the binomial expansion formula. Instead, we show that using a procedure based on dynamic random networks, diploid equilibrium can be achieved spontaneously by a population of agents reproducing sexually in a Mendelian fashion. The model can be used to conduct simulations with a wide range of initial population sizes and genotype distr…